A human neutrophil interacting with Klebsiella pneumoniae (pink), a multidrug-resistant bacterium. Credit: NIAID.

I would like to sound one note of warning. Penicillin is to all intents and purposes non-poisonous so there is no need to worry about giving an overdose and poisoning the patient. There may be a danger, though, in underdosage. It is not difficult to make microbes resistant to penicillin in the laboratory by exposing them to concentrations not sufficient to kill them, and the same thing has occasionally happened in the body

The scientist who discovered penicillin used his Nobel speech to warn us of antibiotic resistance.
↩︎ Nobel Prize
Feb 7, 2017

The scale of the superbug problem is massive.

Ten million people could die per year by 2050 from antibiotic-resistant diseases. That’s about how many people die from heart attack every year now. And a lot of therapies like chemo and transplants may become more dangerous because they expose the body to a higher rate of infection

There will be nothing exceptional about superbugs. They will be normal, and they'll drive up meat prices, kill our forests, and make childbirth more dangerous.

Feb 7, 2017

Antibiotics don't have to be ingested to cause bacteria to evolve. As this mini doc shows, the water near Hyderabad, India is so saturated with antibiotics from a pharmaceutical facility, it causes deathly infections to bloom. 

Despite several promising moonshots, there's no proven alternative waiting to succeed antibiotics as the miracle drug.

Modifying existing antibiotics may add a new generation of antibiotics, but bacteria will eventually evolve to resist them, too. Soap won't stop antibiotic-resistant infections, but scientists are looking to a variety of more advanced technologies that could slow their advance: 

CRISPR-based therapies could use manipulated bacteria to neuter resistance. 

Machine learning to generate novel antibiotics. (Technical paper here.)

—"Phage therapy"—which is where you get injected with viruses from pond water—can combine with antibiotics to checkmate bacteria.

Implementing any of these strategies, as well as shorter term tactics, requires more cooperation between doctors, pharmaceutical companies, and governments than has previously gathered. The only sure thing? Prescribing fewer antibiotics was found to be a key strategy to curb C. Difficile outbreaks in the United Kingdom.

Feb 7, 2017
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